Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy

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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is a common disabling complication of diabetes. Almost half of the patients with DPN develop neuropathic pain (NeuP) for which current analgesic treatments are inadequate. Understanding the role of genetic variability in the development of painful DPN is needed for improved understanding of pain pathogenesis for better patient stratification in clinical tria...

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Painful peripheral neuropathy associated with voriconazole use.

BACKGROUND Voriconazole is a new antifungal agent that has been recently introduced into clinical practice. We found no published reports of painful peripheral neuropathy associated with its use. OBJECTIVE To describe a unique case of painful peripheral neuropathy associated with voriconazole use. SETTING University hospital. PATIENT A 43-year-old patient who had undergone liver transplan...

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Treating Painful Diabetic Peripheral Neuropathy: An Update.

Painful diabetic peripheral neuropathy occurs in approximately 25% of patients with diabetes mellitus who are treated in the office setting and significantly affects quality of life. It typically causes burning pain, paresthesias, and numbness in a stocking-glove pattern that progresses proximally from the feet and hands. Clinicians should carefully consider the patient's goals and functional s...

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Painful Peripheral Neuropathy.

Treatment of neuropathic pain is the primary focus of management for many patients with painful peripheral neuropathies. Neuropathic pain is a common feature of many peripheral neuropathies including those associated with diabetes, uremia, HIV infection, and alcohol abuse. Pain is also present in the majority of patients with idiopathic sensory and sensorimotor polyneuropathies. A growing numbe...

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Painful Diabetic Neuropathy

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ژورنال

عنوان ژورنال: Pain

سال: 2017

ISSN: 0304-3959,1872-6623

DOI: 10.1097/j.pain.0000000000001116