Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
نویسندگان
چکیده
منابع مشابه
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Diabetic peripheral neuropathy (DPN) is a common disabling complication of diabetes. Almost half of the patients with DPN develop neuropathic pain (NeuP) for which current analgesic treatments are inadequate. Understanding the role of genetic variability in the development of painful DPN is needed for improved understanding of pain pathogenesis for better patient stratification in clinical tria...
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BACKGROUND Voriconazole is a new antifungal agent that has been recently introduced into clinical practice. We found no published reports of painful peripheral neuropathy associated with its use. OBJECTIVE To describe a unique case of painful peripheral neuropathy associated with voriconazole use. SETTING University hospital. PATIENT A 43-year-old patient who had undergone liver transplan...
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Painful diabetic peripheral neuropathy occurs in approximately 25% of patients with diabetes mellitus who are treated in the office setting and significantly affects quality of life. It typically causes burning pain, paresthesias, and numbness in a stocking-glove pattern that progresses proximally from the feet and hands. Clinicians should carefully consider the patient's goals and functional s...
متن کاملPainful Peripheral Neuropathy.
Treatment of neuropathic pain is the primary focus of management for many patients with painful peripheral neuropathies. Neuropathic pain is a common feature of many peripheral neuropathies including those associated with diabetes, uremia, HIV infection, and alcohol abuse. Pain is also present in the majority of patients with idiopathic sensory and sensorimotor polyneuropathies. A growing numbe...
متن کاملPainful Diabetic Neuropathy
N europathic pain exerts a substantial impact on quality of life, particularly by causing considerable interference in sleep, daily activities, and enjoyment of life. Chronic neuropathic pain is present in 13–26% of diabetic patients (1– 4). In a recent survey from Augsburg, Germany, the prevalence of painful polyneuropathy was found to be 13.3% in diabetic subjects, 8.7% in individuals with im...
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ژورنال
عنوان ژورنال: Pain
سال: 2017
ISSN: 0304-3959,1872-6623
DOI: 10.1097/j.pain.0000000000001116